The Effects of Creatine Supplementation on Total Work Output and Metabolism During High-Intensity Intermittent Exercise.

The effects of creatine supplementation on endurance and metabolism during high intensity intermittent exercise was examined using 18 males and females (age 19-26). The subjects were randomly divided into 2 groups (creatine and placebo) and the testing proceeded in two phases. During phase 1 both groups received a placebo. During phase 2 the placebo group again received a placebo, while the creatine group received creatine. Testing consisted of a several high intensity intermittent cycling protocols on a stationary cycle ergometer. Both groups performed all test bouts (in random order) in phase 1 and again in phase 2. Testing consisted of: Continuous (Bout A)--Continuos pedaling at 150% VO2 peak until exhaustion. 30/60 (Bout B)--30 seconds of pedaling at 150% VO2 peak followed by 60 seconds rest, repeated until exhaustion. 20/40 (Bout C)--20 seconds pedaling at 150% VO2 peak followed by 40 seconds rest, repeated until exhaustion. 10/20 (Bout D)--10 seconds pedaling at 150% VO2 peak followed by 20 seconds rest, repeated until exhaustion. The placebo group showed no significant change in time to exhaustion from phase 1 to phase 2 for any of the bouts tested. The creatine group, however, showed a significant increase in time to exhaustion on all bouts. Bout D was impacted significantly pedaling at 150% VO2 peak followed by 20 seconds rest, repeated until exhaustion. The placebo group showed no significant change in time to exhaustion from phase 1 to phase 2 for any of the bouts tested. The creatine group, however, showed a significant increase in time to exhaustion on all bouts. Bout D was impacted significantly more than the other bouts with a more than twofold increase in time to exhaustion. (note that bout D was truncated before subjects reached exhaustion because even at twice the performance time of phase 1 subjects reported feeling very little fatigue and the ability to continue indefinitely). Oxygen consumption showed no change from phase 1 to phase 2 for the placebo group, while the creatine group showed a significantly lower rate of oxygen consumption on bouts D and C. Blood lactic acid values were also lower on bouts C and D for the creatine group only. Creatine supplementation also led to significantly increased urinary creatinine concentrations. Therefore creatine supplementation significantly impacted performance of high intensity intermittent exercise

Selectivity of cyclodextrins as a parameter to tune the formation of pseudorotaxanes and micelles supramolecular assemblies. A systematic SANS study

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.We studied the formation of polypseudorotaxanes formed with cyclodextrins (CDs) threading a copolymer chain that forms self-assembled structures in water. The size of the CD cavity was chosen such that it is block selective with respect to the formation of inclusion complexes and therefore in terms of altering the structure of the copolymer self-assemblies in a systematic fashion. Small angle neutron scattering (SANS) experiments provide a direct and clear picture of the shape and interactions of the copolymer micelles in the absence and the presence of various CDs. Moreover, the dissolution of copolymer micelles by CD addition was clearly described by a simple model which provides a tool for quantitative predictions. This study suggests the possibility of designing materials with tunable aggregation abilities in water, where the extent of aggregate formation is determined by the amount and type of added cyclodextrin.EC/FP7/226507/EU/Integrated Infrastructure Initiative for Neutron Scattering and Muon Spectroscopy/NMI

Design and Implementation of a Mobile Exergaming Platform

This paper describes the design, implementation, and initial testing of a reusable platform for the creation of pervasive games with geo-localization services. We concentrate on role-playing games built by combining several types of simpler mini-games having three major components: Quests; Collectables; and Non-player characters (NPC). Quests encourage players to be active in their physical environment and take part in collaborative play; Collectables provide motivation; and NPCs enable player-friendly interaction with the platform. Each of these elements poses different technical requirements, which were met by implementing the gaming platform using the inTrack pervasive middle-ware being developed by our group. Several sample games were implemented and tested within the urban environment of Kyoto, Japan, using gaming clients running on mobile phones from NTT DoCoMo, Japan's largest mobile provider.Comment: 8 pages, 3 figures, International Conference on Intelligent Technologies for Interactive Entertainment, INTETAIN 200

Army-NASA aircrew/aircraft integration program. Phase 5: A3I Man-Machine Integration Design and Analysis System (MIDAS) software concept document

This is the Software Concept Document for the Man-machine Integration Design and Analysis System (MIDAS) being developed as part of Phase V of the Army-NASA Aircrew/Aircraft Integration (A3I) Progam. The approach taken in this program since its inception in 1984 is that of incremental development with clearly defined phases. Phase 1 began in 1984 and subsequent phases have progressed at approximately 10-16 month intervals. Each phase of development consists of planning, setting requirements, preliminary design, detailed design, implementation, testing, demonstration and documentation. Phase 5 began with an off-site planning meeting in November, 1990. It is expected that Phase 5 development will be complete and ready for demonstration to invited visitors from industry, government and academia in May, 1992. This document, produced during the preliminary design period of Phase 5, is intended to record the top level design concept for MIDAS as it is currently conceived. This document has two main objectives: (1) to inform interested readers of the goals of the MIDAS Phase 5 development period, and (2) to serve as the initial version of the MIDAS design document which will be continuously updated as the design evolves. Since this document is written fairly early in the design period, many design issues still remain unresolved. Some of the unresolved issues are mentioned later in this document in the sections on specific components. Readers are cautioned that this is not a final design document and that, as the design of MIDAS matures, some of the design ideas recorded in this document will change. The final design will be documented in a detailed design document published after the demonstrations

Metal-free syn-dioxygenation of alkenes

Reactions employing inexpensive reagents from sustainable sources and with low toxicity are becoming increasingly desirable from an academic and industrial perspective. A fascinating example of a synthetic transformation that requires development of alternative procedures is the osmium catalysed dihydroxylation. Recently there has been considerable interest in achieving this reaction through metal-free procedures. This review describes the methods available for metal-free syn-dioxygenation of alkenes

Episodic medication adherence in adolescents and young adults with perinatally acquired HIV:a within participants approach

Due to the success of antiretroviral (ART) medications, young people living with perinatally acquired HIV (PHIV+) are now surviving into adolescence and young adulthood. Understanding factors influencing ART non-adherence in this group is important in developing effective adherence interventions. Most studies of ART adherence in HIV-positive populations assess differences in adherence levels and adherence predictors between participants, over a period of time (global adherence). Many individuals living with HIV, however, including PHIV+ young people, take medication inconsistently. To investigate this pattern of adherence, a within-participants design, focussing on specific episodes of adherence and non-adherence, is suitable (episodic adherence). A within-participants design was used with 29 PHIV+ young people (17 female, median age 17 years, range 14–22 years), enrolled in the UK Adolescents and Adults Living with Perinatal HIV cohort study. Participants were eligible if they could identify one dose of medication taken and one dose they had missed in the previous two months. For each of the two episodes (one adherent, one non-adherent), behavioural factors (whom they were with, location, routine, day, reminders) and psychological factors at the time of the episode (information about medication, adherence motivation, perceived behavioural skills to adhere to medication – derived from the Information-Motivation-Behavioural Skills (IMB) Model – and affect) were assessed in a questionnaire. Non-adherence was significantly associated with weekend days (Friday to Sunday versus Monday to Thursday, p = .001), lack of routine (p = .004), and being out of the home (p = .003), but not with whom the young person was with or whether they were reminded to take medication. Non-adherence was associated with lower levels of behavioural skills (p < .001), and lower positive affect (p = .005). Non-adherence was not significantly associated with negative affect, information about ART, or ART motivation. The use of situationally specific strategies to enhance adherence in young people who take their medication inconsistently is proposed

Impact of an informed choice invitation on uptake of screening for diabetes in primary care (DICISION): trial protocol.

BACKGROUND: Screening invitations have traditionally been brief, providing information only about population benefits. Presenting information about the limited individual benefits and potential harms of screening to inform choice may reduce attendance, particularly in the more socially deprived. At the same time, amongst those who attend, it might increase motivation to change behavior to reduce risks. This trial assesses the impact on attendance and motivation to change behavior of an invitation that facilitates informed choices about participating in diabetes screening in general practice. Three hypotheses are tested: 1. Attendance at screening for diabetes is lower following an informed choice compared with a standard invitation. 2. There is an interaction between the type of invitation and social deprivation: attendance following an informed choice compared with a standard invitation is lower in those who are more rather than less socially deprived. 3. Amongst those who attend for screening, intentions to change behavior to reduce risks of complications in those subsequently diagnosed with diabetes are stronger following an informed choice invitation compared with a standard invitation. METHOD/DESIGN: 1500 people aged 40-69 years without known diabetes but at high risk are identified from four general practice registers in the east of England. 1200 participants are randomized by households to receive one of two invitations to attend for diabetes screening at their general practices. The intervention invitation is designed to facilitate informed choices, and comprises detailed information and a decision aid. A comparison invitation is based on those currently in use. Screening involves a finger-prick blood glucose test. The primary outcome is attendance for diabetes screening. The secondary outcome is intention to change health related behaviors in those attenders diagnosed with diabetes. A sample size of 1200 ensures 90% power to detect a 10% difference in attendance between arms, and in an estimated 780 attenders, 80% power to detect a 0.2 sd difference in intention between arms. DISCUSSION: The DICISION trial is a rigorous pragmatic denominator based clinical trial of an informed choice invitation to diabetes screening, which addresses some key limitations of previous trials.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Impact of an informed choice invitation on uptake of screening for diabetes in primary care (DICISION): randomised trial

Objective To compare the effect of an invitation promoting informed choice for screening with a standard invitation on attendance and motivation to engage in preventive action

Towards demonstration of photonic payload for telecom satellites

To address the challenges of the Digital Agenda for Europe (DAE) and also to remain in line with the evolution of terrestrial communications in a globally connected world, a major increase in telecoms satellites capacity is required in the near future. With telecom satellites payloads based on traditional RF equipment, increase in capacity and flexibility has always translated into a more or less linear increase in equipment count, mass, power consumption and power dissipation. The main challenge of next generation of High Throughput Satellites (HTS) is therefore to provide a ten-fold-increased capacity with enhanced flexibility while maintaining the overall satellite within a "launchable" volume and mass envelope [1], [2], [3]. Photonic is a very promising technology to overcome the above challenges. The ability of Photonic to handle high data rates and high frequencies, as well as enabling reduced size, mass, immunity to EMI and ease of harness routing (by using fibre-optic cables) is critical in this scenario